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J Pediatr Gastroenterol Nutr. 2012 Oct;55(4):366-9.

Circulating microRNA is a biomarker of biliary atresia.

Author information

1
Division of Gastroenterology and Nutrition, Department of Pediatrics, University of Pennsylvania School of Medicine, Children's Hospital of Philadelphia Research Institute, Philadelphia, PA 19104, USA.

Abstract

OBJECTIVE:

The lack of reliable noninvasive diagnostic biomarkers of biliary atresia (BA) results in delayed diagnosis and worsened patient outcome. Circulating microRNAs (miRNAs) are a new class of noninvasive biomarkers with encouraging diagnostic utility.

METHODS:

We examined the ability of serum miRNAs to distinguish BA from other forms of neonatal hyperbilirubinemia. BA-specific serum miRNAs were identified using a microfluidic array platform and validated in a larger, independent sample set.

RESULTS:

The miR-200b/429 cluster was significantly increased in the sera of patients with BA relative to infants with non-BA cholestatic disorders.

CONCLUSIONS:

Circulating levels of the miR-200b/429 cluster are elevated in infants with BA and have promising diagnostic clinical performance.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT00061828.

PMID:
22732895
PMCID:
PMC3459263
DOI:
10.1097/MPG.0b013e318264e648
[Indexed for MEDLINE]
Free PMC Article

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