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Curr Opin Endocrinol Diabetes Obes. 2012 Aug;19(4):263-70. doi: 10.1097/MED.0b013e328355b7fe.

Insights into type 1 diabetes provided by genetic analyses.

Author information

1
Centre for Diabetes Research, The Western Australian Institute for Medical Research, University of Western Australia, Perth, Western Australia, Australia. gem@waimr.uwa.edu.au

Abstract

PURPOSE OF REVIEW:

Recent identification of over 60 loci contributing to the susceptibility of developing type 1 diabetes (T1D) provides a timely opportunity to assess what is currently known of the genetics of T1D, and what these discoveries may tell us about the disease itself.

RECENT FINDINGS:

The major findings will be discussed under five main themes: T1D risk gene identification, molecular mechanisms of susceptibility, shared genetic cause with other diseases, development of novel analytical methods, and understanding disease heterogeneity.

SUMMARY:

The plethora of T1D risk genes that have been identified risk overwhelming clinicians with lists of gene names and symbols that have little bearing on management, and provide a challenge for researchers to place the genetics of T1D in a more amenable clinical context.

PMID:
22732486
DOI:
10.1097/MED.0b013e328355b7fe
[Indexed for MEDLINE]

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