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BMC Res Notes. 2012 Jun 25;5:327. doi: 10.1186/1756-0500-5-327.

A functional tonB gene is required for both virulence and competitive fitness in a chinchilla model of Haemophilus influenzae otitis media.

Author information

1
Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, 73104, USA. dmorton@ouhsc.edu

Abstract

BACKGROUND:

Haemophilus influenzae requires heme for aerobic growth and possesses multiple mechanisms to obtain this essential nutrient.

METHODS:

An insertional mutation in tonB was constructed and the impact of the mutation on virulence and fitness in a chinchilla model of otitis media was determined. The tonB insertion mutant strain was significantly impacted in both virulence and fitness as compared to the wildtype strain in this model.

CONCLUSIONS:

The tonB gene of H. influenzae is required for the establishment and maintenance of middle ear infection in this chinchilla model of bacterial disease.

PMID:
22731867
PMCID:
PMC3425130
DOI:
10.1186/1756-0500-5-327
[Indexed for MEDLINE]
Free PMC Article

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