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Ann N Y Acad Sci. 2012 Jul;1258:19-24. doi: 10.1111/j.1749-6632.2012.06512.x.

HIV infection and the intestinal mucosal barrier.

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1
Department of Gastroenterology, Infectious Diseases and Rheumatology, Charité- Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany. hans-joerg.epple@charite.de

Abstract

HIV infection induces a barrier defect of the intestinal mucosa, which is closely linked to immune activation and CD4 T cell depletion. The HIV-induced barrier defect is initiated in early acute and maintained through chronic infection. In acute infection, increased epithelial permeability is associated with increased epithelial apoptosis possibly caused by perforin-expressing cytotoxic T cells. In chronic infection, mucosal production of inflammatory cytokines is associated with increased epithelial permeability, epithelial apoptosis, and alterations of epithelial tight junctions. In addition to HIV-induced immune-mediated effects, viral proteins have the potential to directly affect epithelial barrier function. After prolonged viral suppression by antiretroviral therapy, there is, at least partial, restoration of the HIV-associated intestinal mucosal barrier defect despite persisting alterations of the mucosal immune system.

[Indexed for MEDLINE]

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