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Int J Psychiatry Clin Pract. 2013 Feb;17(1):2-9. doi: 10.3109/13651501.2012.687452. Epub 2012 Jun 26.

Factors associated with relapse in patients with schizophrenia.

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  • 1Department of Child and Adolescent Psychiatry, Hospital Sant Joan de Déu , CIBERSAM, Esplugues del Llobregat, Barcelona, Spain. 12636lsm@comb.cat

Abstract

OBJECTIVE:

To assess risk factors for relapse in patients with schizophrenia attended in daily practice.

METHODS:

Patients with schizophrenia admitted consecutively to short-stay/acute-care psychiatric units over a 6-month period were eligible. Variables statistically significant in the univariate logistic regression analysis were then subjected to multivariate analysis.

RESULTS:

The study population included 1646 patients (67.6% men). In the univariate analysis, low family support, duration of illness > 5 years, number of previous hospitalizations, cocaine and cannabis consumption, and number of different antipsychotic drug classes were risk factors for relapse. In the multivariate analysis, number of previous hospitalizations (odds ratio [OR] 1.29, 95% confidence interval [CI] 1.21-1.36) and number of different antipsychotics previously used (OR = 1.13, 95% CI 1.03-1.24) were significant predictors of relapse. The absence of cannabis consumption was a protective factor (OR = 0.72, 95% CI 0.58-0.89). Neither adherence to treatment in the previous 3 years nor type of antipsychotic regimen was significantly associated with relapse.

CONCLUSIONS:

Number of previous hospitalizations and number of different types of antipsychotic drugs were associated with relapse. Absence of cannabis consumption was a protective factor.

PMID:
22731397
DOI:
10.3109/13651501.2012.687452
[PubMed - indexed for MEDLINE]
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