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Protein Cell. 2012 Aug;3(8):618-26. doi: 10.1007/s13238-012-2938-0. Epub 2012 Jun 22.

Bulk-like endocytosis plays an important role in the recycling of insulin granules in pancreatic beta cells.

Author information

1
National Key Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.

Abstract

Although bulk endocytosis has been found in a number of neuronal and endocrine cells, the molecular mechanism and physiological function of bulk endocytosis remain elusive. In pancreatic beta cells, we have observed bulk-like endocytosis evoked both by flash photolysis and trains of depolarization. Bulk-like endocytosis is a clathrin-independent process that is facilitated by enhanced extracellular Ca(2+) entry and suppressed by the inhibition of dynamin function. Moreover, defects in bulk-like endocytosis are accompanied by hyperinsulinemia in primary beta cells dissociated from diabetic KKAy mice, which suggests that bulk-like endocytosis plays an important role in maintaining the exo-endocytosis balance and beta cell secretory capability.

PMID:
22729398
PMCID:
PMC4875361
DOI:
10.1007/s13238-012-2938-0
[Indexed for MEDLINE]
Free PMC Article

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