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Nat Neurosci. 2012 Jun 24;15(8):1105-7. doi: 10.1038/nn.3145.

Activation of lateral habenula inputs to the ventral midbrain promotes behavioral avoidance.

Author information

1
University of North Carolina Neurobiology Curriculum, UNC Neuroscience Center, UNC at Chapel Hill, Chapel Hill, North Carolina, USA.

Abstract

Lateral habenula (LHb) projections to the ventral midbrain, including the rostromedial tegmental nucleus (RMTg), convey negative reward-related information, but the behavioral ramifications of selective activation of this pathway remain unexplored. We found that exposure to aversive stimuli in mice increased LHb excitatory drive onto RMTg neurons. Furthermore, optogenetic activation of this pathway promoted active, passive and conditioned behavioral avoidance. Thus, activity of LHb efferents to the midbrain is aversive but can also serve to negatively reinforce behavioral responding.

PMID:
22729176
PMCID:
PMC3411914
DOI:
10.1038/nn.3145
[Indexed for MEDLINE]
Free PMC Article

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