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Intern Med. 2012;51(12):1537-42. Epub 2012 Jun 15.

Membranoproliferative glomerulonephritis in Castleman's disease: a systematic review of the literature and 2 case reports.

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Kidney Disease Center, the First Affiliated Hospital, College of Medicine, Zhejiang University, China.


We report two cases of membranoproliferative glomerulonephritis, involved in Castleman's disease of hyaline vascular variant and mixed variant, respectively. The diagnoses were confirmed by cervical lymph node and renal biopsy. Both cases were sensitive to chemotherapy with cyclophosphamide, vindesine and prednisone (COP). With the experience from treating case 1, which was misdiagnosed 9 years previously, we followed a more vigilant approach toward case 2 and achieved a more timely diagnosis. Finally, we reviewed pertinent literature of diagnosis and therapy to facilitate an early diagnosis of rare cases in the future.

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