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Gynecol Oncol. 2012 Oct;127(1):22-6. doi: 10.1016/j.ygyno.2012.06.020. Epub 2012 Jun 20.

A multi-institutional cohort study of adjuvant therapy in stage I-II uterine carcinosarcoma.

Author information

1
Division of Gynecologic Oncology, University of Virginia Health System, Charlottesville, VA 22908, USA. lac6vz@virginia.edu

Abstract

OBJECTIVE:

To evaluate the impact of adjuvant post-operative therapy in women with early stage uterine carcinosarcoma.

METHODS:

After IRB approval was obtained at all sites, a multi-center retrospective study of women with FIGO stage I-II uterine carcinosarcoma diagnosed from 1997 to 2007 was conducted. Post-operative treatment included observation (OBS), radiation (RT), chemotherapy (CT) alone or with RT (CT+RT). Data analyzed included demographic and pathologic factors, adjuvant therapy outcomes, and time-to-event information. The Kaplan-Meier method was used to estimate time-to-event functions. Cox regression modeling was used to examine the impact of selected covariates on progression free survival (PFS), and overall survival (OS).

RESULTS:

111 women were identified: 94 (85%) had stage I and 17 (15%) had stage II uterine carcinosarcoma. Forty-four women (40%) did not receive adjuvant therapy (OBS), 29 (26%) women had adjuvant CT, 23 (20%) women underwent RT and 15 (14%) women underwent RT+CT. Seventy-three patients were alive without disease and 38 had progressed or died at the close of data collection. In multivariate analysis, CT (p=0.003), LVSI (p<0.0001) and a pre-existing cancer (p=0.004) were most predictive of PFS. LVSI was predictive of shortened OS (p=0.01).

CONCLUSIONS:

In women with FIGO stage I-II uterine carcinosarcoma, adjuvant chemotherapy is associated with improved PFS compared to radiation or observation alone. Ongoing clinical trials will clarify the role of chemotherapy in women with this disease.

PMID:
22727985
DOI:
10.1016/j.ygyno.2012.06.020
[Indexed for MEDLINE]

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