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Bioorg Med Chem Lett. 2012 Jul 15;22(14):4528-31. doi: 10.1016/j.bmcl.2012.05.125. Epub 2012 Jun 7.

Exploration of diverse hinge-binding scaffolds for selective Aurora kinase inhibitors.

Author information

1
Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064-6100, USA. zhiqin.ji@abbott.com

Abstract

Four hinge-binding scaffolds have been explored for novel selective Aurora kinase inhibitors. The structure activity relationship, selectivity and pharmacokinetic profiles have been evaluated.

PMID:
22727637
DOI:
10.1016/j.bmcl.2012.05.125
[Indexed for MEDLINE]

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