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Phys Life Rev. 2012 Sep;9(3):219-63. doi: 10.1016/j.plrev.2012.06.001. Epub 2012 Jun 13.

Evolutionary dynamics of RNA-like replicator systems: A bioinformatic approach to the origin of life.

Author information

1
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, 8600 Rockville Pike, Bethesda, MD 20894, USA. takeuchi@ncbi.nlm.nih.gov

Abstract

We review computational studies on prebiotic evolution, focusing on informatic processes in RNA-like replicator systems. In particular, we consider the following processes: the maintenance of information by replicators with and without interactions, the acquisition of information by replicators having a complex genotype-phenotype map, the generation of information by replicators having a complex genotype-phenotype-interaction map, and the storage of information by replicators serving as dedicated templates. Focusing on these informatic aspects, we review studies on quasi-species, error threshold, RNA-folding genotype-phenotype map, hypercycle, multilevel selection (including spatial self-organization, classical group selection, and compartmentalization), and the origin of DNA-like replicators. In conclusion, we pose a future question for theoretical studies on the origin of life.

PMID:
22727399
PMCID:
PMC3466355
DOI:
10.1016/j.plrev.2012.06.001
[Indexed for MEDLINE]
Free PMC Article

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