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FEBS J. 2013 Jan;280(2):681-93. doi: 10.1111/j.1742-4658.2012.08670.x. Epub 2012 Jul 17.

Type 2C protein phosphatases in plants.

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Department of Botany, Technische Universität München, Freising, Germany.


Type 2C protein phosphatases (PP2Cs) form a structurally unique class of Mg(2+)-/Mn(2+)-dependent enzymes. PP2Cs are evolutionary conserved from prokaryotes to higher eukaryotes and play a prominent role in stress signalling. In this review, we focus on the evolution, function and regulation of the plant PP2Cs. Members of a subclass of plant PP2Cs counteract mitogen-activated protein kinase pathways, whereas members of other subfamilies function as co-receptors for the phytohormone abscisic acid. Recent structural analyses of abscisic acid receptors have elucidated the mode of ligand-dependent regulation and substrate targeting.

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