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Chem Biol. 2012 Jun 22;19(6):664-5. doi: 10.1016/j.chembiol.2012.06.002.

Cell-free screening for NOX inhibitors.

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1
Department of Pathology, Dalhousie University, Halifax, B3H 4R2, Canada.

Abstract

NOX enzymes are major ROS generators in pathological states and represent a promising pharmacological target. In this issue of Chemistry & Biology, Smith and colleagues developed an original and elegant cell-free assay to identify specific Nox2 inhibitors in a high throughput manner.

PMID:
22726678
DOI:
10.1016/j.chembiol.2012.06.002
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