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Cell. 2012 Jun 22;149(7):1438-45. doi: 10.1016/j.cell.2012.06.003.

RNA polymerase backtracking in gene regulation and genome instability.

Author information

1
Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016, USA. evgeny.nudler@nyumc.org

Abstract

RNA polymerase is a ratchet machine that oscillates between productive and backtracked states at numerous DNA positions. Since its first description 15 years ago, backtracking--the reversible sliding of RNA polymerase along DNA and RNA--has been implicated in many critical processes in bacteria and eukaryotes, including the control of transcription elongation, pausing, termination, fidelity, and genome instability.

PMID:
22726433
PMCID:
PMC3815583
DOI:
10.1016/j.cell.2012.06.003
[Indexed for MEDLINE]
Free PMC Article

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