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Cell. 2012 Jun 22;149(7):1431-7. doi: 10.1016/j.cell.2012.06.006.

A movie of RNA polymerase II transcription.

Author information

1
Gene Center and Department of Biochemistry, Center for Integrated Protein Science Munich, Ludwig-Maximilians-Universit√§t M√ľnchen, Munich, Germany.

Abstract

We provide here a molecular movie that captures key aspects of RNA polymerase II initiation and elongation. To create the movie, we combined structural snapshots of the initiation-elongation transition and of elongation, including nucleotide addition, translocation, pausing, proofreading, backtracking, arrest, reactivation, and inhibition. The movie reveals open questions about the mechanism of transcription and provides a useful teaching tool.

PMID:
22726432
DOI:
10.1016/j.cell.2012.06.006
[Indexed for MEDLINE]
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