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Cell. 2012 Jun 22;149(7):1426-7. doi: 10.1016/j.cell.2012.06.007.

Tiki casts a spell on Wnt.

Author information

1
MRC's National Institute for Medical Research, London NW7 1AA, UK. jvincen@nimr.mrc.ac.uk

Abstract

Negative feedback is a widespread feature of signaling pathways. In an unexpected twist described in this issue, He and colleagues identify a membrane-tethered metalloprotease named Tiki that inhibits Wnt signaling by removing an essential eight-residue fragment from Wnt itself.

PMID:
22726430
DOI:
10.1016/j.cell.2012.06.007
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