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Cell. 2012 Jun 22;149(7):1424-5. doi: 10.1016/j.cell.2012.06.004.

Membrane protein structure predictions for exploration.

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Howard Hughes Medical Institute, Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390-9050, USA.


A daring experiment is performed. Using sequence alignments to predict contacts between residues in protein spatial structures, Hopf et al. are publishing untested de novo structure models for 11 transmembrane protein families. Will their models stand the test of time and hold up to experimentation? The prospects are excellent.

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