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Horm Metab Res Suppl. 1990;24:66-71.

Application of structural model of glucose-insulin relations to assess beta-cell function and insulin sensitivity.

Author information

1
Diabetes Research Laboratories, Radcliffe Infirmary, Oxford, United Kingdom.

Abstract

A structural mathematical model of glucose-insulin relationships based on known quantitative responses of the major organs involved with glucose metabolism has been computed. Different degrees of beta-cell function and insulin sensitivity can be included, and the effect of their interaction assessed (i) in a steady state, basal homeostasis after an overnight fast and (ii) in response to a glucose infusion. By comparing a patient's basal plasma glucose and insulin (or C-peptide) concentrations with the predictions of a basal homeostatic model, the degree of impairment of beta-cell function and insulin sensitivity can be assessed. Similarly, the plasma glucose and insulin (or C-peptide) concentrations after a continuous glucose infusion can also be compared with predictions from the model to estimate beta-cell function and insulin sensitivity. These assessments of pathophysiology can be applied to data from individual patients or to patient populations.

PMID:
2272629
[Indexed for MEDLINE]

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