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J Am Geriatr Soc. 2012 Jul;60(7):1244-52. doi: 10.1111/j.1532-5415.2012.04045.x. Epub 2012 Jun 21.

Angiotensin-converting enzyme inhibitor use by older adults is associated with greater functional responses to exercise.

Author information

1
Department of Aging and Geriatric Research, University of Florida College of Medicine, Gainesville, Florida 32607, USA. tbuford@ufl.edu

Abstract

OBJECTIVES:

To assess the association between angiotensin converting enzyme inhibitors (ACEis) and improvements in the physical function of older adults in response to chronic exercise training.

DESIGN:

Secondary analysis of the Lifestyle Interventions and Independence for Elders Pilot (LIFE-P) study, a multisite randomized clinical trial to evaluate the effects of chronic exercise on the physical function of older adults at risk for mobility disability.

SETTING:

Four academic research centers within the United States.

PARTICIPANTS:

Four hundred twenty-four individuals aged 70 to 89 with mild to moderate functional impairments categorized for this analysis as ACEi users, users of other antihypertensive drugs, or antihypertensive nonusers.

INTERVENTION:

A 12-month intervention of structured physical activity (PA) or health education promoting successful aging (SA).

MEASUREMENTS:

Change in walking speed during a 400-m test and performance on a battery of short-duration mobility tasks (Short Physical Performance Battery (SPPB)).

RESULTS:

Physical activity significantly improved the adjusted walking speed of ACEi users (P < .001) but did not of nonusers. PA improved the adjusted SPPB score of ACEi users (P < .001) and of persons who used other antihypertensive drugs (P = .005) but not of antihypertensive nonusers (P = .91).The percentage of ACEi users deriving clinically significant benefit from exercise training for walking speed (30%) and SPPB score (48%) was dramatically higher than for nonusers (14% and 12%, respectively).

CONCLUSION:

For older adults at risk for disability, exercise-derived improvements in physical function were greater for ACEi users than users of other antihypertensive drugs and antihypertensive nonusers.

PMID:
22726232
PMCID:
PMC3625953
DOI:
10.1111/j.1532-5415.2012.04045.x
[Indexed for MEDLINE]
Free PMC Article
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