Format

Send to

Choose Destination
Immunol Rev. 2012 Jul;248(1):205-15. doi: 10.1111/j.1600-065X.2012.01126.x.

Mechanisms regulating regional localization of inflammation during CNS autoimmunity.

Author information

1
Department of Immunology, University of Washington, Seattle, WA 98195, USA.

Abstract

Multiple sclerosis (MS) is a disease of the central nervous system (CNS) characterized by inflammatory, demyelinating lesions localized in the brain and spinal cord. Experimental autoimmune encephalomyelitis (EAE) is an animal model of MS that is induced by activating myelin-specific T cells and exhibits immune cell infiltrates in the CNS similar to those seen in MS. Both MS and EAE exhibit disease heterogeneity, reflecting variations in clinical course and localization of lesions within the CNS. Collectively, the differences seen in MS and EAE suggest that the brain and spinal cord function as unique microenvironments that respond differently to infiltrating immune cells. This review addresses the roles of the cytokines interferon-γ and interleukin-17 in determining the localization of inflammation to the brain or spinal cord in EAE.

PMID:
22725963
PMCID:
PMC3678350
DOI:
10.1111/j.1600-065X.2012.01126.x
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center