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J Proteome Res. 2012 Aug 3;11(8):4102-9. doi: 10.1021/pr300137n. Epub 2012 Jul 10.

Deconvolution of targeted protein-protein interaction maps.

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CeMM-Center for Molecular Medicine of the Austrian Academy of Sciences, AKH-BT 25.3, Lazarettgasse 14, A-1090 Vienna, Austria.


Current proteomic techniques allow researchers to analyze chosen biological pathways or an ensemble of related protein complexes at a global level via the measure of physical protein-protein interactions by affinity purification mass spectrometry (AP-MS). Such experiments yield information-rich but complex interaction maps whose unbiased interpretation is challenging. Guided by current knowledge on the modular structure of protein complexes, we propose a novel statistical approach, named BI-MAP, complemented by software tools and a visual grammar to present the inferred modules. We show that the BI-MAP tools can be applied from small and very detailed maps to large, sparse, and much noisier data sets. The BI-MAP tool implementation and test data are made freely available.

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