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Diabetes Care. 2012 Jul;35(7):1429-35. doi: 10.2337/dc12-0033.

Liver fat is reduced by an isoenergetic MUFA diet in a controlled randomized study in type 2 diabetic patients.

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  • 1Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy.

Abstract

OBJECTIVE:

To evaluate the effects of qualitative dietary changes and the interaction with aerobic exercise training on liver fat content independent of weight loss in patients with type 2 diabetes.

RESEARCH DESIGN AND METHODS:

With use of a factorial 2 × 2 randomized parallel-group design, 37 men and 8 women, aged 35-70 years, with type 2 diabetes in satisfactory blood glucose control on diet or diet plus metformin treatment were assigned to one of the following groups for an 8-week period: 1) high-carbohydrate/high-fiber/low-glycemic index diet (CHO/fiber group), 2) high-MUFA diet (MUFA group), 3) high-carbohydrate/high-fiber/low-glycemic index diet plus physical activity program (CHO/fiber+Ex group), and 4) high-MUFA diet plus physical activity program (MUFA+Ex group). Before and after intervention, hepatic fat content was measured by (1)H NMR.

RESULTS:

Dietary compliance was optimal and body weight remained stable in all groups. Liver fat content decreased more in MUFA (-29%) and MUFA+Ex (-25%) groups than in CHO/fiber (-4%) and CHO/fiber+Ex groups (-6%). Two-way repeated-measures ANOVA, including baseline values as covariate, showed a significant effect on liver fat content for diet (P = 0.006), with no effects for exercise training (P = 0.789) or diet-exercise interaction (P = 0.712).

CONCLUSIONS:

An isocaloric diet enriched in MUFA compared with a diet higher in carbohydrate and fiber was associated with a clinically relevant reduction of hepatic fat content in type 2 diabetic patients independent of an aerobic training program and should be considered for the nutritional management of hepatic steatosis in people with type 2 diabetes.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT01025856.

PMID:
22723581
PMCID:
PMC3379578
DOI:
10.2337/dc12-0033
[PubMed - indexed for MEDLINE]
Free PMC Article
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