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J Med Microbiol. 2012 Oct;61(Pt 10):1417-20. doi: 10.1099/jmm.0.038968-0. Epub 2012 Jun 21.

Transposons and integrons in colistin-resistant clones of Klebsiella pneumoniae and Acinetobacter baumannii with epidemic or sporadic behaviour.

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Instituto de Educación Medica e Investigaciones Clínicas 'Dr Norberto Quirno' CEMIC, Buenos Aires, Argentina.


Multiple transposons, integrons and carbapenemases were found in Klebsiella pneumoniae colistin-resistant isolates as well as a genomic resistance island of the AbaR type in Acinetobacter baumannii colistin-resistant isolates from different hospitals from Buenos Aires City. PFGE analysis showed a polyclonal dissemination of antimicrobial resistance mechanisms among K. pneumoniae isolates, while in A. baumannii isolates the epidemic clone 1 from South America was found. Resistance determinants associated with horizontal gene transfer are contributing to the evolution to pandrug resistance in both epidemic and sporadic clones.

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