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Environ Health Perspect. 1990 Aug;88:251-3.

Growth control in mammalian cells by cell-cell contacts.

Author information

1
Institute of Toxicology, Johannes Gutenberg University, Mainz, Federal Republic of Germany.

Abstract

Growth of normal diploid mammalian cells in vitro is strongly regulated by the actual cell density. Cell-cell contacts via specific plasma membrane glycoproteins whose glycan moieties interact with specific receptors has been found to be a main growth regulatory principle. Malignant growth is suggested to result from impaired function of these receptors.

PMID:
2272319
PMCID:
PMC1567996
DOI:
10.1289/ehp.9088251
[Indexed for MEDLINE]
Free PMC Article

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