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Pediatr Surg Int. 2012 Oct;28(10):953-9. Epub 2012 Jun 22.

Is complete surgical resection of stage 4 neuroblastoma a prerequisite for optimal survival or may >95 % tumour resection suffice?

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1
Department of Paediatric Surgery, Wilhelmina Children's Hospital, University Medical Centre Utrecht, PO Box 85090, 3508, Utrecht, The Netherlands. s.zwaveling@umcutrecht.nl

Abstract

Numerous studies have shown that for optimal survival in localized International Neuroblastoma Staging System stage 1-3 neuroblastoma, complete tumour resection (CR, macroscopic total tumour removal) is usually mandatory. In contrast, it is conceivable that in stage 4 disseminated disease, less extensive surgery [gross total resection (GTR), >95 % tumour removal] may suffice. This review shows substantial survival benefit in studies reporting on stage 4 patients undergoing CR, but also in studies reporting on patients undergoing GTR. Comparison between these studies is severely hampered by treatment heterogeneity. We found only four studies that explicitly compared survival between patients undergoing either CR or GTR. Two of these studies showed favourable results for patients treated with CR, while the other two did not show differences in survival.

PMID:
22722825
PMCID:
PMC3445800
DOI:
10.1007/s00383-012-3109-3
[Indexed for MEDLINE]
Free PMC Article
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