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Dig Dis. 2012;30(2):154-7. doi: 10.1159/000336668. Epub 2012 Jun 20.

The role of obesity in gastroesophageal reflux disease and Barrett's esophagus.

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Department of Internal Medicine and Gastroenterology, University of Bologna, Italy.


The prevalence of gastroesophageal reflux disease (GERD) and related disorders has been increasing worldwide, particularly in Western populations where a parallel rise in obesity prevalence has been reported. As weight gain often overlaps with the GERD-related symptoms, several recent studies investigated the significance of this correlation, mainly using meta-analyses. Here, we discuss the large amount of evidence linking obesity and GERD-related symptoms, providing potential mechanisms for their co-occurrence. Particular attention is given also to the association between obesity, Barrett's esophagus and esophageal adenocarcinoma development.

[Indexed for MEDLINE]

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