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Nature. 2012 Jun 20;486(7403):335-40. doi: 10.1038/nature11170.

Engineering H5N1 avian influenza viruses to study human adaptation.

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1
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. dm270q@nih.gov

Abstract

Two studies of H5N1 avian influenza viruses that had been genetically engineered to render them transmissible between ferrets have proved highly controversial. Divergent opinions exist about the importance of these studies of influenza transmission and about potential 'dual use' research implications. No consensus has developed yet about how to balance these concerns. After not recommending immediate full publication of earlier, less complete versions of the studies, the United States National Science Advisory Board for Biosecurity subsequently recommended full publication of more complete manuscripts; however, controversy about this and similar research remains.

PMID:
22722191
PMCID:
PMC3731044
DOI:
10.1038/nature11170
[Indexed for MEDLINE]
Free PMC Article
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