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Curr Opin Virol. 2012 Aug;2(4):408-18. doi: 10.1016/j.coviro.2012.05.006. Epub 2012 Jun 20.

Towards a human rotavirus disease model.

Author information

1
Division of Molecular Virology, University of Linköping, 581 85, Linköping, Sweden.

Abstract

While the clinical importance of human rotavirus (RV) disease is well recognized and potent vaccines have been developed, our understanding of how human RV causes diarrhoea, vomiting and death remains unresolved. The fact that oral rehydration corrects electrolyte and water loss, indicates that enterocytes in the small intestine have a functional sodium-glucose co-transporter. Moreover, RV infection delays gastric emptying and loperamide appears to attenuate RV diarrhoea, thereby suggesting activation of the enteric nervous system. Serotonin (5-HT) receptor antagonists attenuate vomiting in young children with gastroenteritis while zinc and enkephalinase inhibitors attenuate RV-induced diarrhoea. In this review we discuss clinical symptoms, pathology, histology and treatment practices for human RV infections and compile the data into a simplified disease model.

PMID:
22722079
DOI:
10.1016/j.coviro.2012.05.006
[Indexed for MEDLINE]

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