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Cancer Res. 2012 Jul 1;72(13):3125-30. doi: 10.1158/0008-5472.CAN-11-4094. Epub 2012 Jun 21.

Cellular constituents of immune escape within the tumor microenvironment.

Author information

1
Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. kerkars@mail.nih.gov

Abstract

Established tumors are complex masses that contain not only neoplastic cells but also nontransformed cellular elements such as stromal cells, the neovasculature, and the full gamut of immune cells. However, evidence suggests that, unlike cells found in lymphoid organs that productively respond to acute infections, immune cells in tumors are dysregulated and functionally impaired. Tumor masses can contain regulatory lymphocytes, myeloid-derived suppressor cells, alternatively activated macrophages, and dendritic cells. Ablation or reprogramming of this aberrant microenvironment might dramatically augment cancer therapies, and this strategy is currently being deployed in a variety of clinical trials. A better understanding of the cellular constituents of tumors and the mechanisms involved in immune evasion may help guide the next generation of innovative cancer immunotherapies.

PMID:
22721837
PMCID:
PMC6327310
DOI:
10.1158/0008-5472.CAN-11-4094
[Indexed for MEDLINE]
Free PMC Article

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