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Int J Gynaecol Obstet. 2012 Sep;118(3):242-6. doi: 10.1016/j.ijgo.2012.04.014. Epub 2012 Jun 20.

Gynecologic disorders and menstrual cycle lightheadedness in postural tachycardia syndrome.

Author information

1
Paden Autonomic Dysfunction Service, Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, USA.

Abstract

OBJECTIVE:

To assess differences in gynecologic history and lightheadedness during menstrual cycle phases among patients with POTS and healthy control women.

METHODS:

In a prospective, questionnaire-based study carried out at Paden Autonomic Dysfunction Center, Vanderbilt University, between April 2005 and January 2009, a custom-designed questionnaire was administered to patients with POTS (n=65) and healthy individuals (n=95). The results were analyzed via Fisher exact test and Mann-Whitney U test.

RESULTS:

Patients with POTS reported increased lightheadedness through all phases of the menstrual cycle phases as compared with healthy controls. Both groups experienced the greatest lightheadedness during menses, and a decrease in lightheadedness during the follicular phase. Patients with POTS reported a higher incidence of gynecologic diseases as compared with healthy controls.

CONCLUSION:

The severity of lightheadedness was found to vary during the menstrual cycle, which may relate to changes in estrogen levels. Patients with POTS also reported an increase in estrogen-related gynecologic disease.

PMID:
22721633
PMCID:
PMC3413773
DOI:
10.1016/j.ijgo.2012.04.014
[Indexed for MEDLINE]
Free PMC Article

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