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Cancer Treat Rev. 1990 Sep;17(2-3):247-52.

In vivo antitumor activity of ilmofosine.

Author information

1
Boehringer Mannheim GmbH, Department of Immunopharmacology, F.R.G.

Abstract

Ilmofosine is a cytostatic/cytotoxic thioether phospholipid derivative. The in vivo anti-tumour activity of this compound was investigated in a methylcholanthrene (MethA)-induced fibrosarcoma and in the 3Lewis-lung carcinoma systems, respectively. Ilmofosine showed antineoplastic and antimetastatic properties at oral doses ranging from 0.625 to 40 mg/kg/day. Combination of Ilmofosine (p.o.) together with either cyclophosphamide (p.o.) or cis-DDP (i.v.) resulted in synergistic effects in vivo. These results demonstrate the in vivo antitumour activity of Ilmofosine in two tumour systems. The data indicate that direct cytostatic/cytotoxic effects of Ilmofosine are mainly responsible for its antitumour activity in vivo and which are increased by other cytotoxics.

PMID:
2272040
DOI:
10.1016/0305-7372(90)90055-k
[Indexed for MEDLINE]

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