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Oncoimmunology. 2012 Mar 1;1(2):217-218.

The double-edge sword effect of anti-CD73 cancer therapy.

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Centre de Recherche du Centre Hospitalier de l'Université de Montréa; Faculté de Pharmacie et Institut du Cancer de Montréal; Montréal, Québec, Canada.


We and others have identified CD73 as a new cancer target. I hereafter discuss that targeted blockade of CD73 has the effect of a "double-edge sword," able on the one hand to rescue endogenous adaptive anti-tumor immune responses, and on the other hand, inhibit the metastatic potential of tumor cells.

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