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Oncoimmunology. 2012 Jan 1;1(1):103-105.

Antibody-dependent cell cytotoxicity in monoclonal antibody-mediated tumor immunotherapy.

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1
Institut Curie; Centre de Recherche; Paris, France ; INSERM; U93; Paris, France.

Abstract

Antibody-dependent cell cytotoxicity (ADCC) is critical in monoclonal antibody (mAb)-mediated cancer therapy. We recently showed that a tumor-specific mAb in combination with cyclophosphamide inhibited tumor cell growth and induced ADCC-synapses between tumor and effector cells in vivo, opening perspectives to enhance anti-tumor responses by manipulating the immune system.

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