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Dement Geriatr Cogn Dis Extra. 2012 Jan;2:180-6. doi: 10.1159/000338174. Epub 2012 Apr 20.

The Relationship between Subclinical Asperger's Syndrome and Frontotemporal Lobar Degeneration.

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Department of Psychology, Chuo University, Tokyo, Japan.



The existence of the behavioral variant of frontotemporal dementia (bv-FTD), including senile Asperger's syndrome (AS), has been proposed. However, there are no empirical case reports to support the proposal. In this report, we present 3 patients who showed symptoms of bv-FTD and demonstrated signs of autistic spectrum disorder, especially AS.


We evaluated 3 subjects using the diagnostic criteria for bv-FTD, and their caregivers retrospectively provided data to calculate the Autism-Spectrum Quotient, Japanese version [Wakabayashi et al.: Shinrigaku Kenkyu 2004;75:78-84]. We also compared these data with those obtained from 3 individuals with Alzheimer's disease.


All 3 patients met the criteria for bv-FTD and had a higher Autism-Spectrum Quotient score than did comparable Alzheimer's disease subjects.


It is possible that some senile persons with frontotemporal lobar degeneration-like maladaptive behavior may suffer from subclinical AS.


Asperger's syndrome; Autistic spectrum disorders; Frontotemporal dementia; Premorbid characteristics

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