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J Clin Microbiol. 2012 Sep;50(9):3077-9. doi: 10.1128/JCM.01485-12. Epub 2012 Jun 20.

Effect of manganese in test media on in vitro susceptibility of Enterobacteriaceae and Acinetobacter baumannii to tigecycline.

Author information

1
Laboratory for Microbiology and Infection Control, Amphia Hospital, Breda, The Netherlands.

Abstract

We assessed the effect of increasing manganese concentrations in test media (0.001 to 1,024 mg/liter) on MICs of tigecycline. For both broth microdilution (BMD) and Etests, this effect was negligible for physiological concentrations, but MICs increased when concentrations exceeded 8 mg/liter. Susceptibility testing should be performed on media with standardized low manganese content.

PMID:
22718943
PMCID:
PMC3421825
DOI:
10.1128/JCM.01485-12
[Indexed for MEDLINE]
Free PMC Article

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