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J Clin Microbiol. 2012 Sep;50(9):2877-80. doi: 10.1128/JCM.01013-12. Epub 2012 Jun 20.

Performance of BinaxNOW for diagnosis of malaria in a U.S. hospital.

Author information

1
Department of Pathology, Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, Stanford, California, USA.

Abstract

Microscopic diagnosis and species identification of Plasmodium in areas of nonendemicity provide a robust method for malaria diagnosis but are technically challenging. A prospective study was conducted to measure the performance of BinaxNOW compared to microscopy (the gold standard) in a U.S. teaching hospital. Overall, BinaxNOW was 84.2% sensitive and 99.8% specific. Excluding patients on antimalarial therapy, the sensitivity was 92.9%. Importantly, BinaxNOW initially misclassified a case of Plasmodium falciparum malaria as non-falciparum. These results support the judicious use of BinaxNOW in screening of individuals suspected of having malaria in areas of nonendemicity.

PMID:
22718936
PMCID:
PMC3421790
DOI:
10.1128/JCM.01013-12
[Indexed for MEDLINE]
Free PMC Article

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