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Sheng Li Xue Bao. 2012 Jun 25;64(3):247-58.

Cell adhesion molecules in human embryo implantation.

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Cancer Center, Sanford-Burnham Medical Research Institute, La Jolla, CA, USA.


The process of human embryo implantation is mediated not only by evolutionarily conserved mechanisms, but also by a mechanism unique to humans. Evidence suggests that the cell adhesion molecules, L-selectin and trophinin, play a unique role in human embryo implantation. Here, we describe the dual roles of mucin carbohydrate ligand for L-selectin and trophinin protein and of the trophinin-associated proteins bystin and tastin. We then describe trophinin-mediated signal transduction in trophectoderm cells and endometrial epithelial cells. This review also covers cadherin and integrin in human embryo implantation.

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