Send to

Choose Destination
Int J Dermatol. 2012 Jul;51(7):848-52. doi: 10.1111/j.1365-4632.2011.05383.x.

Using cold air for reducing needle-injection pain.

Author information

Department of Dermatology, Jordan University of Science and Technology, Irbid, Jordan.



Pain is associated with skin injections. Reducing injection-associated pain is important especially when multiple injections are needed in difficult areas, such as the palms. We present a new safe application for cold air used in laser therapy.


The main objectives of this study are to see whether cold air can reduce needle-injection pain and to evaluate the safety of this new application.


Patients undergoing skin injection (n=40) were included. Assessment of pain level using visual analog scale (VAS) was done using cold air and again without cold air in the same patient. Comparison of pain scores was performed.


Thirty-three patients had lower VAS scores using cold air. Five patients had worse VAS scores, and two patients did not have any change in their pain score. In the group of patients where injections were made to the palms (n=5), there was even more reduction in VAS scores. There were no significant immediate or delayed side effects.


Cold air seems to be useful in reducing needle-injection pain in the majority of patients, especially in the palms. This procedure is safe, apart from immediate tolerable discomfort when used around the nose.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center