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BMJ Case Rep. 2011 Jan 12;2011:3347. doi: 10.1136/bcr.09.2010.3347.

Primary Sjögren's disease and its complications presenting with progressive paralysis.

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1
Critical Care Department, Heartlands Hospital, Birmingham, UK. mattjulian@doctors.org.uk

Abstract

A 24-year-old female presented with generalised weakness, lethargy and aches in legs. She was subsequently found to be markedly hypokalaemic and have a metabolic acidosis. A diagnosis of distal renal tubular acidosis (RTA) was made. In addition to this failure to alkalinise her urine, she was unable to concentrate it and so a diagnosis of nephrogenic diabetes insipidus was reached. Further questioning revealed previous investigation of a connective tissue disorder thought to be primary Sjögren's syndrome. RTA is a recognised but rare complication of Sjögren's syndrome. Urinary alkalinisation using potassium bicarbonate was instituted; the patient responded well to treatment and is having outpatient follow-up.

PMID:
22715234
PMCID:
PMC3029323
DOI:
10.1136/bcr.09.2010.3347
[Indexed for MEDLINE]
Free PMC Article
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