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BMJ Case Rep. 2011 Jan 11;2011. pii: bcr0320102848. doi: 10.1136/bcr.03.2010.2848.

Dyskeratosis congenita with malignant transformation.

Author information

1
Department of Oral and Maxillofacial Pathology, Dr R Ahmed Dental College & Hospital, Kolkata, India. jaygopalray@yahoo.co.in

Abstract

Dyskeratosis congenita (DC) is a rare genodermatosis characterised by a classic triad of dystrophic nails, reticular skin pigmentation and mucous membrane leukoplakic patches, which have a high rate of malignant transformation. The case report presented here deals with a sporadic case of DC without similar clinical presentation in the first-degree and second-degree relatives. Of note in this case, there was rapid malignant transformation in the non-homogeneous nodulo-speckled leukoplakic patch on the dorsum of the tongue.

PMID:
22715219
PMCID:
PMC3029444
DOI:
10.1136/bcr.03.2010.2848
[Indexed for MEDLINE]
Free PMC Article
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