Synthesis of aza-fused polycyclic quinolines via double C-H bond activation

Chemistry. 2012 Jul 16;18(29):8896-900. doi: 10.1002/chem.201201207. Epub 2012 Jun 19.

Abstract

Simple but efficient: Aza-fused polycyclic quinolines were efficiently assembled through rhodium(III)-based direct double C-H activation of N-aryl azoles followed by cyclization with alkynes without heteroatom-assisted chelation. Copper(II) acetate, aside from acting as an oxidant, could also play an important role in the C-H activation process.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aza Compounds / chemical synthesis*
  • Aza Compounds / chemistry*
  • Copper / chemistry*
  • Cyclization
  • Hydrogen Bonding
  • Molecular Structure
  • Polycyclic Compounds / chemical synthesis*
  • Polycyclic Compounds / chemistry
  • Quinolines / chemical synthesis
  • Quinolines / chemistry
  • Rhodium / chemistry*

Substances

  • Aza Compounds
  • Polycyclic Compounds
  • Quinolines
  • Copper
  • Rhodium