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Autophagy. 2012 Jun;8(6):979-81. doi: 10.4161/auto.20232. Epub 2012 Jun 1.

Hypoxia-induced tumor cell autophagy mediates resistance to anti-angiogenic therapy.

Author information

1
Department of Neurosurgery, Diller Cancer Research Building, University of California at San Francisco (UCSF), San Francisco, CA, USA.

Abstract

While anti-angiogenic therapy was initially greeted enthusiastically by the cancer community, initial successes with this therapeutic modality were tempered by the failure of angiogenesis inhibitors to produce sustained clinical responses in most patients, with resistance to the inhibitors frequently developing. We recently reported that hypoxia increases after the devascularization caused by anti-angiogenic therapy, consistent with the goals of these therapies, but that some tumor cells become resistant and survive the hypoxic insult elicited by anti-angiogenic therapy through autophagy by activating both AMPK and HIF1A pathways. These findings suggest that modulating the autophagy pathway may someday allow anti-angiogenic therapy to fulfill its therapeutic potential. However, further work will clearly be needed to develop more potent and specific autophagy inhibitors and to better understand the regulators of autophagy in malignant cells.

PMID:
22714142
PMCID:
PMC3427265
DOI:
10.4161/auto.20232
[Indexed for MEDLINE]
Free PMC Article

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