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J Atten Disord. 2014 Feb;18(2):117-22. doi: 10.1177/1087054712448960. Epub 2012 Jun 19.

Prepulse inhibition of acoustic startle and the influence of methylphenidate in children with ADHD.

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1
1University Hospital Schleswig-Holstein, Campus Kiel, Germany.

Abstract

OBJECTIVE:

ADHD is common among children with comorbidity of enuresis. Findings concerning prepulse inhibition (PPI) of startle reflexes are controversial. Although PPI is improved through desamino-arginine vasopressin (dDAVP) in enuresis, some patients also improve concomitant ADHD through dDAVP. This study aims to evaluate whether methylphenidate (MPH) also improves PPI in ADHD.

METHOD:

Nineteen ADHD patients were investigated in a prospective, double-blind, crossover study with MPH versus placebo. PPI was measured as a reduction of acoustic startle reflexes. Subgroups of gender, ADHD subtype, and baseline PPI were analyzed.

RESULTS:

Median baseline PPI of ADHD patients (51.7%) was below the value of age-matched normal controls (73%, p = .090). MPH showed no improvement in the whole group, or the subgroups gender or subtype. Reduced baseline PPI was significantly improved (22.5%-39.3%, p = .039).

CONCLUSION:

Heterogeneity of ADHD is confirmed with a wide range of baseline PPI. The improvement of reduced baseline PPI through MPH suggests impaired sensorimotor gating in this subgroup.

KEYWORDS:

Attention-Deficit/Hyperactivity Disorder; methylphenidate; prepulse inhibition; subgroups

PMID:
22713361
DOI:
10.1177/1087054712448960
[Indexed for MEDLINE]
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