Format

Send to

Choose Destination
Breast Cancer Res. 2012 Jun 19;14(3):313.

Prognostic signatures in breast cancer: correlation does not imply causation.

Author information

1
The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London SW3 6JB, UK.

Abstract

Testing the statistical associations between microarray-based gene expression signatures and patient outcome has become a popular approach to infer biological and clinical significance of laboratory observations. Venet and colleagues recently demonstrated that the majority of randomly generated gene signatures are significantly associated with outcome of breast cancer patients, and that this association stems from the fact that a large proportion of the transcriptome is significantly correlated with proliferation, a strong predictor of outcome in breast cancer patients. These findings demonstrate that a statistical association between a gene signature and disease outcome does not necessarily imply biological significance.

PMID:
22713235
PMCID:
PMC3446329
DOI:
10.1186/bcr3173
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for BioMed Central Icon for PubMed Central
Loading ...
Support Center