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Clin Cancer Res. 2012 Jul 1;18(13):3495-8. doi: 10.1158/1078-0432.CCR-12-1456. Epub 2012 Jun 18.

The quest for self-identity: not all cancer stem cells are the same.

Author information

1
Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA. richj@ccf.org

Abstract

A central critique of the cancer stem cell (CSC) hypothesis involves the robustness of CSC markers. Zorniak and colleagues suggest that different progenitor marker profiles can classify CSCs, and improved modeling of cellular hierarchies can be achieved by incorporating inter- and intratumoral diversity.

PMID:
22711710
PMCID:
PMC3389128
DOI:
10.1158/1078-0432.CCR-12-1456
[Indexed for MEDLINE]
Free PMC Article
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