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J Nephrol. 2013 Mar-Apr;26(2):315-22. doi: 10.5301/jn.5000147. Epub 2012 Jun 11.

Hemodialysis prescription education decreases intradialytic hypotension.

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Department of Medicine, University of Calgary, Calgary, Alberta - Canada; and Department of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.



Intradialytic hypotension (IDH) is associated with increased morbidity and mortality. We studied the impact of an education program and hemodialysis (HD) prescription optimization on the frequency of IDH.


We compared chronic HD patients during 2 retrospective time periods: a control period and the study period which occurred after 2 months of physician education and HD prescription optimization. Primary study outcomes were the frequency of HD sessions complicated by IDH, and the prevalence of IDH-prone patients.


There were 91 and 82 patients in the control and study periods, respectively. In the study period, 11% (115/1107) of HD sessions were complicated by IDH vs. 17% (189/1103) in the control period (p = 0.0002). There was a decreased odds ratio for IDH in the study period compared with control (odds ratio [OR] = 0.59; 95% confidence interval [95% CI], 0.40-0.86; p = 0.007). Compared with control, more patients in the study period were prescribed at least 2 preventative strategies (42% vs. 61%, p = 0.02), including increased use of cool dialysate (55% vs. 89%, p<0.001). Cool dialysate reduced the odds of IDH by 50% (OR = 0.50; 95% CI, 0.30-0.86; p = 0.012).


HD prescription education with concurrent use of multiple preventative strategies is associated with a significant decrease in IDH.

[Indexed for MEDLINE]

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