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Oncol Rep. 2012 Sep;28(3):931-6. doi: 10.3892/or.2012.1862. Epub 2012 Jun 12.

Novel function of MKP-5/DUSP10, a phosphatase of stress-activated kinases, on ERK-dependent gene expression, and upregulation of its gene expression in colon carcinomas.

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1
Division of Cancer Chemotherapy, Miyagi Cancer Center Research Institute, Miyagi 981-1293, Japan.

Abstract

Mitogen-activated protein kinase phosphatase 5 (MKP-5)/DUSP10 acts as a phosphatase of stress-activated kinases (JNK and p38), but its activity towards ERK has not been demonstrated. In the present study we observed that MKP-5 interacts with ERK, retains it in the cytoplasm, suppresses its activation and downregulates ERK-dependent transcription. These data suggested a novel MKP-5 function as a scaffold protein for the ERK pathway. We analyzed MKP-5 gene expression in several tumors, and found that it is frequently upregulated in colorectal but not in lung and breast cancer, suggesting its association with the malignant phenotype of colon cancer.

PMID:
22711061
DOI:
10.3892/or.2012.1862
[Indexed for MEDLINE]
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