Format

Send to

Choose Destination
Chem Commun (Camb). 2012 Jul 25;48(58):7304-6. doi: 10.1039/c2cc33476c. Epub 2012 Jun 18.

Microarray-guided discovery of two-photon (2P) small molecule probes for live-cell imaging of cysteinyl cathepsin activities.

Author information

1
Department of Chemistry, National University of Singapore, 3 Science Drive 3, 117543, Singapore.

Abstract

A microarray immobilized with 105 aldehyde-containing small molecules was screened against mammalian cell lysates over-expressing cathepsin L to identify two potent inhibitors, which were subsequently converted into cell-permeable probes capable of live-cell imaging of endogenous cysteinyl cathepsin activities by two-photon fluorescence microscopy.

PMID:
22711056
DOI:
10.1039/c2cc33476c
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Royal Society of Chemistry
Loading ...
Support Center