Abstract
A new approach to total syntheses of piperidine alkaloids (+)-241D, isosolenopsin and isosolenopsin A has been developed from D-alanine. The key step to access the chiral pyridinone intermediate was achieved via a gold mediated cyclization. Finally, various reduction conditions afforded the natural products in few steps and good overall yields.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alanine / chemistry
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Alkaloids / chemical synthesis*
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Alkaloids / chemistry
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Catalysis
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Cyclization
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Gold / chemistry*
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Piperidines / chemical synthesis*
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Piperidines / chemistry
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Pyridones / chemistry
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Stereoisomerism
Substances
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241D dendrobate alkaloid
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Alkaloids
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Piperidines
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Pyridones
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Solenopsin A
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Gold
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Alanine