Abstract
SnoN (Ski-novel protein) plays an important role in embryonic development, tumorigenesis and aging. Past studies largely focused on its roles in tumorigenesis. Recent studies of its expression patterns and functions in mouse models and mammalian cells have revealed that SnoN interacts with multiple signaling molecules at different cellular levels to modulate the activities of several signaling pathways in a tissue context and developmental stage dependent manner. These studies suggest that SnoN may have broad functions in the embryonic development and tissue morphogenesis.
Copyright © 2012 Federation of European Biochemical Societies. All rights reserved.
Publication types
-
Research Support, N.I.H., Extramural
-
Review
MeSH terms
-
Animals
-
Axons / metabolism
-
Cell Cycle
-
Cell Movement
-
Cell Proliferation
-
Drosophila
-
Gene Expression Regulation, Developmental*
-
Gene Expression Regulation, Neoplastic
-
Genes, Tumor Suppressor
-
Humans
-
Intracellular Signaling Peptides and Proteins / physiology*
-
Models, Biological
-
Morphogenesis
-
Neurons / metabolism
-
Protein Isoforms / metabolism
-
Proto-Oncogene Proteins / biosynthesis*
-
Proto-Oncogene Proteins / physiology*
-
Signal Transduction
-
Transforming Growth Factor beta / metabolism
Substances
-
Intracellular Signaling Peptides and Proteins
-
Protein Isoforms
-
Proto-Oncogene Proteins
-
SKIL protein, human
-
Transforming Growth Factor beta